36 research outputs found

    Performance evaluation of Vehicular Ad Hoc Networks over high speed environment using NCTUns

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    Català: Cada any aproximadament un milió dues-centes mil persones moren en accidents de trànsit. D'aquesta dada es desprèn que els accidents de trànsit són la quarta causa de mortalitat al món. Degut a això, un gran nombre de governs i els majors fabricants de vehicles del món estan invertint temps i diners en recerca i desenvolupament per millorar la seguretat a les carreteres. Amb aquest objectiu, apareix el concepte de VANET: Vehicular Ad-hoc NETwork. Una VANET està basada en vehicles i estacions base intel·ligents que comparteixen informació a través de comunicacions inalàmbriques. Aquest intercanvi de dades podria tenir un gran impacte en la seguretat viària i la qualitat en la conducció però a més a més seria una nova font d' entreteniment mòbil. La millora en seguretat implicaria una reducció en el nombre d'accidents i les comunicacions inalàmbriques usades en mobilitat permetrien una optimització del transport. L'evolució de les VANETs en els últims anys i les seves aplicacions útils a les carreteres són les principals raons per dur a terme aquest projecte. El gran suport a aquest tipus de xarxes inalàmbriques sembla indicar que les VANETs són les xarxes del futur en entorns mòbils. En relació al projecte, el primer problema observat és que el protocol que s'usa específicament en VANETs (802.11p) només està disponible en pocs simuladors de xarxa i està en fase de desenvolupament. Per tant, la majoria de les funcions no estan implementades i això fa que el protocol no sigui madur. En conseqüència, es va triar un protocol àmpliament usat com és 802.11b per fer les proves en el simulador NCTUns. L?objectiu del projecte és avaluar el funcionament de VANETs usant el protocol 802.11b i el protocol d?encaminament AODV en un escenari d?autopista. Ajustant diferents paràmetres com el nombre de cotxes, la seva velocitat i el seu rang de cobertura és possible obtenir variacions en les mesures de pèrdues, throughput i retard extrem-a-extrem en la xarxa. El resultat final és que les mesures permeten saber quines són les comunicacions que es produeixen a la xarxa per cadascuna de les configuracions i la seva incidència en les condicions de conducció.Castellano: Cada año cerca de un millón doscientas mil personas fallecen en accidentes de tráfico. De este dato se desprende que los accidentes de tráfico son la cuarta causa de mortalidad en el mundo. Debido a esto, un gran número de gobiernos y los mayores fabricantes de vehículos del mundo están invirtiendo tiempo y dinero en investigación y desarrollo para mejorar la seguridad en las carreteras. Con este objetivo, aparece el concepto de VANET: Vehicular Ad-hoc NETwork. Una VANET se basa en vehículos y estaciones base inteligentes que comparten información por medio de comunicaciones inalámbricas. Este intercambio de datos podría tener un gran impacto en la seguridad vial y en la calidad de la conducción pero además sería una nueva fuente de entretenimiento móvil. La mejora en la seguridad implicaría una reducción en el número de accidentes y las comunicaciones inalámbricas utilizadas en movilidad permitirían optimizar el transporte. La evolución de las VANETs en los últimos años y sus aplicaciones útiles en las carreteras son las principales razones para llevar a cabo este proyecto. El gran apoyo a este tipo de redes inalámbricas parece indicar que las VANETs son las redes del futuro en entornos móviles. En relación al proyecto, el primer problema observado es que el protocolo específicamente utilizado en VANETs (802.11p) sólo está disponible en pocos simuladores de red y se encuentra en fase de desarrollo. Por lo tanto, la mayoría de funciones no están implementadas y esto hace que el protocolo no sea maduro. En consecuencia, se escogió un protocolo ampliamente utilizado como es 802.11b para realizar las pruebas en el simulador NCTUns. El objetivo del proyecto es evaluar el funcionamiento de VANETs utilizando el protocolo 802.11b y el protocolo de encaminamiento AODV en un escenario de autopista. Ajustando diferentes parámetros como el número de coches, su velocidad y su rango de cobertura es posible obtener variaciones en las medidas de pérdidas, throughput y retardo extremo-a-extremo en la red. El resultado final es que las medidas permiten saber cuáles son las comunicaciones que se producen en la red para cada una de las configuraciones y su incidencia en las condiciones de conducción.English: Every year about 1.2 million people die because of traffic accidents [1]. This means that traffic accidents are the fourth cause of mortality in the world. Therefore, several governments and the most important car manufacturers are investing time and money on research and development in order to improve road safety. At this respect, appears the concept of VANET: Vehicular Ad-hoc NETwork. A VANET is based on smart cars and base-stations that share information via wireless communications. This interchange of data may have a great impact on safety and driving quality but also could be another source of mobile entertainment. This improvement on safety would imply reducing the number of accidents. In addition, the use of wireless communications in mobility would lead to an optimization of transport. The evolution of VANETs in the last years and their useful applications on the road has been the main reason to develop this project. The great support of many people to this type of wireless networks suggests that VANETs are the networks of the future in mobile environments. Regarding the project, the first problem encountered is that the network protocol specially designed for VANETs, IEEE 802.11p, is only available in a few of the network simulators and is on phase of development. This fact means that most of the functions are not implemented so it cannot be considered as a mature protocol. As a consequence, a widely used protocol as IEEE 802.11b was chosen and all the tests were performed on NCTUns simulator. So the purpose of this project is to evaluate the performance of VANETs by using 802.11b protocol and AODV routing protocol in a highway scenario. By adjusting different parameters like number of cars, their speed and their range of coverage, variations on measures of loss ratio, throughput and end-to- end delay were detected on the network. Finally, the measures help to know about network communications for each of the cases and their incidence on driving conditions

    Spanish National Hip Fracture Registry (RNFC) : First-year results and comparison with other registries and prospective multi-centric studies from Spain

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    Fundamentos: El Registro Nacional de Fracturas de Cadera (RNFC) es un registro español multicéntrico, prospectivo y continuo, que comenzó en 2017. El objetivo de este artículo fue presentar los datos del primer informe anual y compararlos con los registros autonómicos y los estudios multicéntricos realizados recientemente en España. Métodos: Se incluyeron las personas de 75 años o más atendidas con el diagnóstico de fractura de cadera por fragilidad en alguno de los hospitales participantes en el RNFC, entre enero y octubre de 2017. En el análisis estadístico se utilizó la media y desviación estándar o mediana y rangos intercuartílicos para las variables numéricas y los porcentajes para las variables categóricas. Se realizó un análisis descriptivo global de la casuística y se comparó con los datos disponibles de los estudios previos mencionados. Resultados: Se registraron 7.208 personas de 54 hospitales, con una edad media de 86,7 años (DE 5,6). El 75,4% fueron mujeres y el 36,4% presentaron deterioro cognitivo previo. La demora quirúrgica media fue de 75,7 horas (DE 63,6) y la estancia media fue de 10,9 días (DE 6,7). De las personas que vivían en un domicilio antes de la fractura (75,4%), menos de la mitad (37,0%) volvieron a él tras el alta hospitalaria. Al mes, había fallecido el 7,1%. La comparación con los otros estudios mostró algunas diferencias importantes, sobre todo en la ubicación previa, en el porcentaje de pacientes institucionalizados de novo (7,7-29,4%) y en el porcentaje con tratamiento antiosteoporótico al alta (14,5-36,7%). Conclusiones: El RNFC es la mayor base de datos prospectiva que aporta datos sobre el perfil de los pacientes hospitalizados por fractura de cadera en España. La comparación con otros estudios recientes muestra algunas diferencias importantes.OBJECTIVE: The Spanish National Hip Fracture Registry (Registro Nacional de Fracturas de Cadera or RNFC) is a Spanish, prospective, multi- centric registry, commenced in 2017. The goal of this paper is to present the data from the first annual report and to compare them with autonomic registries and recent prospective multi-centric studies performed in Spain. METHODS: We included persons 75 years or older treated for fragility hip fractures in any of the centers participating in the RNFC between January and October 2017. The descriptive statistics of each variable used the mean (and standard deviation) or the median (and interquartile ranges) for the ordinal variables and the percentage for the categoric variables. A descriptive analysis of the casemix was performed and compared with available data from the aforementioned studies. RESULTS: The RNFC included 7.208 patients from 54 hospitals, with a mean age of 86.7 (SD 5.6) years; 75.4% were women, and 36.4% showed cognitive decline. Mean surgical delay was 75.7 (SD 63.6) hours, and length of stay averaged 10.9 (SD 6.7) days. Of the patients who lived at home (75.4%), less than half (37.0%) returned home at discharge. One-month mortality was 7.1%. Comparison with other studies showed important differences, especially regarding patients newly sent to nursing homes (7.7-29.4%) and with antiosteoporotic treatment at discharge (14.5-36.7%). CONCLUSIONS: The RNFC is the largest prospective database to date that offers data regarding the characteristics of patients hospitalized for hip fractures in Spain. Comparison with recent studies showed some important differences

    Registro Nacional de Fracturas de Cadera (RNFC): Resultados del primer año y comparación con otros registros y estudios multicéntricos españoles

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    Background: The Spanish National Hip Fracture Registry (Registro Nacional de Fracturas de Cadera or RNFC) is a Spanish, prospective, multi- centric registry, commenced in 2017. The goal of this paper is to present the data from the first annual report and to compare them with autonomic registries and recent prospective multi-centric studies performed in Spain. Methods: We included persons 75 years of age or older treated for fragility hip fractures in any of the centers participating in the RNFC between January and October 2017. The descriptive statistics of each variable used the mean (and standard deviation) or the median (and interquartile ranges) for the ordinal variables and the percentage for the categoric variables. A descriptive analysis of the casemix was performed and compared with available data from the aforementioned studies. Results: The RNFC included 7.208 patients from 54 hospitals, with a mean age of 86.7 (SD 5.6) years; 75.4% were women, and 36.4% showed cognitive decline. Mean surgical delay was 75.7 (SD 63.6) hours, and length of stay averaged 10.9 (SD 6.7) days. Of the patients who lived at home (75.4%), less than half (37.0%) returned home at discharge. One-month mortality was 7.1%. Comparison with other studies showed important differences, especially regarding patients newly sent to nursing homes (7.7-29.4%) and with antiosteoporotic treatment at discharge (14.5-36.7%). Conclusions: The RNFC is the largest prospective database to date that offers data regarding the characteristics of patients hospitalized for hip fractures in Spain. Comparison with recent studies showed some important differencesFundamentos: El Registro Nacional de Fracturas de Cadera (RNFC) es un registro español multicéntrico, prospectivo y continuo, que comenzó en 2017. El objetivo de este artículo fue presentar los datos del primer informe anual y compararlos con los registros autonómicos y los estudios multicéntricos realizados recientemente en España. Métodos: Se incluyeron las personas de 75 años o más atendidas con el diagnóstico de fractura de cadera por fragilidad en alguno de los hospitales participantes en el RNFC, entre enero y octubre de 2017. En el análisis estadístico se utilizó la media y desviación estándar o mediana y rangos intercuartílicos para las variables numéricas y los porcentajes para las variables categóricas. Se realizó un análisis descriptivo global de la casuística y se comparó con los datos disponibles de los estudios previos mencionados. Resultados: Se registraron 7.208 personas de 54 hospitales, con una edad media de 86,7 años (DE 5,6). El 75,4% fueron mujeres y el 36,4% presentaron deterioro cognitivo previo. La demora quirúrgica media fue de 75,7 horas (DE 63,6) y la estancia media fue de 10,9 días (DE 6,7). De las personas que vivían en un domicilio antes de la fractura (75,4%), menos de la mitad (37,0%) volvieron a él tras el alta hospitalaria. Al mes, había fallecido el 7,1%. La comparación con los otros estudios mostró algunas diferencias importantes, sobre todo en la ubicación previa, en el porcentaje de pacientes institucionalizados de novo (7,7-29,4%) y en el porcentaje con tratamiento antiosteoporótico al alta (14,5-36,7%). Conclusiones: El RNFC es la mayor base de datos prospectiva que aporta datos sobre el perfil de los pacientes hospitalizados por fractura de cadera en España. La comparación con otros estudios recientes muestra algunas diferencias importantesThe RNFC has been financed through donations by AMGEN SA, UCB Pharma, Abbott Laboratories and FAES Farma, as well as a Research Grant from the Fundación Mutua Madrileña (AP169672018)

    TransLectures

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    transLectures (Transcription and Translation of Video Lectures) is an EU STREP project in which advanced automatic speech recognition and machine translation techniques are being tested on large video lecture repositories. The project began in November 2011 and will run for three years. This paper will outline the project¿s main motivation and objectives, and give a brief description of the two main repositories being considered: VideoLectures.NET and poliMedia. The first results obtained by the UPV group for the poliMedia repository will also be provided.The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement no. 287755. Funding was also provided by the Spanish Government (iTrans2 project, TIN2009-14511; FPI scholarship BES-2010-033005; FPU scholarship AP2010-4349)Silvestre Cerdà, JA.; Del Agua Teba, MA.; Garcés Díaz-Munío, GV.; Gascó Mora, G.; Giménez Pastor, A.; Martínez-Villaronga, AA.; Pérez González De Martos, AM.... (2012). TransLectures. IberSPEECH 2012. 345-351. http://hdl.handle.net/10251/3729034535

    Smart gated magnetic silica mesoporous particles for targeted colon drug delivery: New approaches for inflammatory bowel diseases treatment

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    [EN] Magnetic mesoporous silica microparticles were loaded with safranin O (S1) and with hydrocortisone (S2) and the outer surface functionalized with a bulky azo derivative bearing urea moieties. Aqueous suspensions of both solids at pH 7.4 showed negligible payload release whereas a marked delivery was observed in the presence of sodium dithionite due to the rupture of the azo bonds. Besides, a moderate cargo release was observed at acidic pH due to the hydrolysis of the urea bonds that linked the azo derivative onto the external surface of the inorganic scaffolds. In vitro digestion models showed that S1 and S2 microparticles could be used for the controlled release of payload in the reducing colon environment (in which azoreductase enzymes are present). On the other hand, in vivo pharmacokinetic studies in rats showed that safranine O release from S1 microparticles was concentrated in colon. The performance of S2 microparticles for the treatment of colitis in rats (induced by oral administration of a 2,4,6-trinitrobenzenesulfonic acid solution) was tested. The controlled release of hydrocortisone from S2 in the colon of injured rats induced marked reduction in colon/body weight ratio and in clinical activity score. Also, histological studies showed a marked decrease in inflammation followed by intensive regeneration and almost normal mucosal structure of the individuals treated with S2. Besides, the use of a magnetic belt increased the therapeutic performances of S2 due to an enhanced retention time of the particles in the colon.We thank the Spanish Government (projects MAT2015-64139-C4-1-R and AGL2015-70235-C2-2-R (MINECO/FEDER)) and the Generalitat Valenciana (project PROMETEOII/2014/047) for support. AHT thanks to the Spanish MEC for his FPU grant. The authors also thank the Electron Microscopy Service at the Universitat Politecnica de Valencia for support. SCSIE (Universitat de Valencia) is also gratefully acknowledged for all the equipment employed. NMR was registered at the U26 facility of ICTS "NANBIOSIS" at the Universitat de Valencia. The authors thanks Dr. L. A. Villaescusa for his helpful discussion about the 1H NMR analysis of the composition of loaded and functionalized supports.Teruel, AH.; Pérez-Esteve, É.; Gonzalez-Alvarez, I.; Gonzalez -Alvarez, M.; Costero, AM.; Ferri, D.; Parra Álvarez, M.... (2018). Smart gated magnetic silica mesoporous particles for targeted colon drug delivery: New approaches for inflammatory bowel diseases treatment. Journal of Controlled Release. 281:58-69. https://doi.org/10.1016/j.jconrel.2018.05.007S586928

    Famílies botàniques de plantes medicinals

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    Facultat de Farmàcia, Universitat de Barcelona. Ensenyament: Grau de Farmàcia, Assignatura: Botànica Farmacèutica, Curs: 2013-2014, Coordinadors: Joan Simon, Cèsar Blanché i Maria Bosch.Els materials que aquí es presenten són els recull de 175 treballs d’una família botànica d’interès medicinal realitzats de manera individual. Els treballs han estat realitzat per la totalitat dels estudiants dels grups M-2 i M-3 de l’assignatura Botànica Farmacèutica durant els mesos d’abril i maig del curs 2013-14. Tots els treballs s’han dut a terme a través de la plataforma de GoogleDocs i han estat tutoritzats pel professor de l’assignatura i revisats i finalment co-avaluats entre els propis estudiants. L’objectiu principal de l’activitat ha estat fomentar l’aprenentatge autònom i col·laboratiu en Botànica farmacèutica

    Plasma lipid profiles discriminate bacterial from viral infection in febrile children

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    Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection are often non-specific, and there is no definitive test for the accurate diagnosis of infection. The 'omics' approaches to identifying biomarkers from the host-response to bacterial infection are promising. In this study, lipidomic analysis was carried out with plasma samples obtained from febrile children with confirmed bacterial infection (n = 20) and confirmed viral infection (n = 20). We show for the first time that bacterial and viral infection produces distinct profile in the host lipidome. Some species of glycerophosphoinositol, sphingomyelin, lysophosphatidylcholine and cholesterol sulfate were higher in the confirmed virus infected group, while some species of fatty acids, glycerophosphocholine, glycerophosphoserine, lactosylceramide and bilirubin were lower in the confirmed virus infected group when compared with confirmed bacterial infected group. A combination of three lipids achieved an area under the receiver operating characteristic (ROC) curve of 0.911 (95% CI 0.81 to 0.98). This pilot study demonstrates the potential of metabolic biomarkers to assist clinicians in distinguishing bacterial from viral infection in febrile children, to facilitate effective clinical management and to the limit inappropriate use of antibiotics

    Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

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    Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

    TFG 2013/2014

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    Amb aquesta publicació, EINA, Centre universitari de Disseny i Art adscrit a la Universitat Autònoma de Barcelona, dóna a conèixer el recull dels Treballs de Fi de Grau presentats durant el curs 2013-2014. Voldríem que un recull com aquest donés una idea més precisa de la tasca que es realitza a EINA per tal de formar nous dissenyadors amb capacitat de respondre professionalment i intel·lectualment a les necessitats i exigències de la nostra societat. El treball formatiu s’orienta a oferir resultats que responguin tant a paràmetres de rigor acadèmic i capacitat d’anàlisi del context com a l’experimentació i la creació de nous llenguatges, tot fomentant el potencial innovador del disseny.Con esta publicación, EINA, Centro universitario de diseño y arte adscrito a la Universidad Autónoma de Barcelona, da a conocer la recopilación de los Trabajos de Fin de Grado presentados durante el curso 2013-2014. Querríamos que una recopilación como ésta diera una idea más precisa del trabajo que se realiza en EINA para formar nuevos diseñadores con capacidad de responder profesional e intelectualmente a las necesidades y exigencias de nuestra sociedad. El trabajo formativo se orienta a ofrecer resultados que respondan tanto a parámetros de rigor académico y capacidad de análisis, como a la experimentación y la creación de nuevos lenguajes, al tiempo que se fomenta el potencial innovador del diseño.With this publication, EINA, University School of Design and Art, affiliated to the Autonomous University of Barcelona, brings to the public eye the Final Degree Projects presented during the 2013-2014 academic year. Our hope is that this volume might offer a more precise idea of the task performed by EINA in training new designers, able to speak both professionally and intellectually to the needs and demands of our society. The educational task is oriented towards results that might respond to the parameters of academic rigour and the capacity for contextual analysis, as well as to considerations of experimentation and the creation of new languages, all the while reinforcing design’s innovative potential

    Comparison of major depression diagnostic classification probability using the SCID, CIDI, and MINI diagnostic interviews among women in pregnancy or postpartum: An individual participant data meta‐analysis

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    OBJECTIVES: A previous individual participant data meta-analysis (IPDMA) identified differences in major depression classification rates between different diagnostic interviews, controlling for depressive symptoms on the basis of the Patient Health Questionnaire-9. We aimed to determine whether similar results would be seen in a different population, using studies that administered the Edinburgh Postnatal Depression Scale (EPDS) in pregnancy or postpartum. METHODS: Data accrued for an EPDS diagnostic accuracy IPDMA were analysed. Binomial generalised linear mixed models were fit to compare depression classification odds for the Mini International Neuropsychiatric Interview (MINI), Composite International Diagnostic Interview (CIDI), and Structured Clinical Interview for DSM (SCID), controlling for EPDS scores and participant characteristics. RESULTS: Among fully structured interviews, the MINI (15 studies, 2,532 participants, 342 major depression cases) classified depression more often than the CIDI (3 studies, 2,948 participants, 194 major depression cases; adjusted odds ratio [aOR] = 3.72, 95% confidence interval [CI] [1.21, 11.43]). Compared with the semistructured SCID (28 studies, 7,403 participants, 1,027 major depression cases), odds with the CIDI (interaction aOR = 0.88, 95% CI [0.85, 0.92]) and MINI (interaction aOR = 0.95, 95% CI [0.92, 0.99]) increased less as EPDS scores increased. CONCLUSION: Different interviews may not classify major depression equivalently
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